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In murine cells, the expression of both genes was induced by hypoxia and correlated strongly with HIF-2, suggesting that globin synthesis in the alveolar epithelium can be induced directly by low O 2 or indirectly through HIF-linked mechanisms

10.1016/j.fct.2018.02.019 352 ZouC.SuN.WuJ.XuM.SunZ.LiuQ.et al (2019)

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The cassette containing hyg5 and a gene encoding 3HB6H under control of the trc promoter, used to synthesise gentisate, was referred to as a GA module (Supplementary Fig

As mentioned earlier, higher doses yield quicker results but may also increase the risk of side effects