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Skin lesions suffered from UVB irradiation shows elevated iron content (64), excessive accumulation of lipid peroxides, and GSH depletion, therefore undergoing ferroptosis in keratinocytes, and then leads to cutaneous necroinflammation and injury (56)

The effect of adding zinc to vitamin A on IGF-1, bone age and linear growth in stunted children

Compared to Supersomes, human S9 and hepatocyte-based assays showed slightly improved metabolite coverage with human liver microsomes providing the closest representation of human in vivo amide hydrolysis (differing from in vivo metabolism in the cases of acetanilide, paracetamol and lidocaine)

The design concept behind ProTide involves the utilization of an aromatic group and an amino acid ester group to mask the hydroxyl moiety of monophosphate/monophosphonate, thereby enabling the resulting prodrug molecules to liberate free nucleoside monophosphate/monophosphonate through intracellular enzymatic catalysis upon cellular internalization, thus facilitating their biological activity