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All statistical analyses were conducted using the TwoSampleMR (for extracting genetic associations where publicly available and harmonization), MendelianRandomization and MRPRESSO (for deriving MR estimates), and meta package (for assessing heterogeneity in sex differences) in R (version 4.0.1, R Foundation for Statistical Computing, Vienna, Austria)

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There is heart disease but no signs or symptoms of heart failure

doi: 10.1152/jn.1998.79.4.1790 43 ShahrakiSEsmaeilpourKShabaniMSepehriGRajizadehMAManeshianMet al