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Some enzymes require certain nutrient cofactors, so nutrient deficiencies can interfere with production

Implications of MMP9 for Blood Brain Barrier Disruption and Hemorrhagic Transformation Following Ischemic Stroke
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Methods of enzymatic analysis 673684 (Elsevier, 1974)

Wakefield AJ, Puleston JM, Montgomery SM, Anthony A, OLeary JJ, Murch SH (2002) The concept of entero-colonic encephalopathy, autism and opioid receptor ligands
