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10.1016/J.CBI.2011.02.016 Chem Biol Interact

T., Ucan U., Boyacioglu M., Ipek E., et al
However, some conjugated metabolites can be directly cytotoxic because of their ability to inhibit enzymes important for cell viability, as well as by inhibition of the conjugating enzymes

Methionine cycle-dependent regulation of T cells in cancer immunity

This suggests that targeting the NA-2AR axis could be a potential strategy for preventing stress-induced hair graying
