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However, misuse or insufficient documentation can lead to frequent claim denials and unnecessary rework

When to reduce or stop: Persistent severe nausea despite dosage adjustment, severe injection site reactions or infection signs, significant blood pressure fluctuations, allergic symptoms, side effects outweighing vision benefits

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This is followed by DNA-damaging agents (20% in approved ADCs, 4.2% in phase III ADCs) and TOP1 inhibitors (13.3% in approved ADCs, 45.8% in phase III ADCs) (Fig

In late 2023, the FDA explicitly flagged BPC-157 as a Category 2 substance, citing concerns about immune reactions, peptide impurities, and lack of safety data for human use