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Ten genes were identified as important regulators of this process, including ferredoxin 1 ( FDX1 ), lipoic acid synthetase ( LIAS ), lipoyltransferase 1 ( LIPT1 ), dihydrolipoamide dehydrogenase ( DLD ), DLAT , pyruvate dehydrogenase E1 subunit alpha 1 ( PDHA1 ), pyruvate dehydrogenase E1 subunit beta ( PDHB ), metal regulatory transcription factor 1 ( MTF1 ), glutaminase ( GLS ), and cyclin dependent kinase inhibitor 2 A ( CDKN2A )
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Network pharmacology highlighted a second functional module composed of GPX1, GSR, GSTP1, and SOD1, enriched in glutathione metabolism and mitochondrial antioxidant activity
Govoni, S., Politi, P
