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As stated by Yonath in 2003 (257), the most significant biological implication of the rotatory motion seems to be the establishment of favorable stereochemistry for peptide bond formation without drastic conformational rearrangements at the PTC

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Interestingly, on undergoing a LOsG/ROS stress, -cells started to re-express fetal nuclear Neurog3 and to dramatically relocate pancreas/duodenum homeobox protein 1 (Pdx1) from the cytoplasm to the nucleus (Fig