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The time to onset of MFS is 742 days, occurring either after post-first or second dose of the COVID-19 vaccine [102,108,109]

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The current standard operating procedure by the European Center for the Validation of Alternative Methods (ECVAM) recommends the use of MTT reduction as parameter to make prediction on the skin irritancy of substances using EpiSkin TM test method, while IL-1 endpoint is regarded as a useful adjunct to MTT assay 48