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Luspatercept stimulates erythropoiesis, increases iron utilization, and redistributes body iron in transfusion-dependent thalassemia

10.2337/diabetes.51.10.2915 ^ Rosenthal M.D., Glew R.H

As a core metabolic product, lactate may promote the release of inflammatory mediators (e.g., IL-6, TNF-) by activating the TGF- signaling pathway, while enhancing NF-B pathway activity to exacerbate local inflammatory infiltration in lung tissue but this direct activation has not been demonstrated in COPD airway cells
Gut 71 (5), 10201032

doi: 10.1038/nature11551 46 LozuponeCAStombaughJIGordonJIJanssonJKKnightR
