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Overexpressing the catalytically inactive variant of human HL was atheroprotective in chow-fed LDL receptorknockout mice lacking endogenous HL [13, 14], whereas no effect on atherosclerosis development was seen in the same model on a Western diet [12]

Located on chromosome 7p15.2, this master regulatory gene is the member of a larger family pertaining to DNA-binding transcription parameteres sharing an utterly conserved 183-nucleotide sequence encoding a 61 amino acid homeodomain

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