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Polymorphisms of these genes or associated regulatory sequences, or copy number variations (CNV) may contribute to a reduction in UGT activity or indeed loss of function and, therefore, reduce paracetamol glucuronidation

Opening at 2 mg weekly rather than 4 mg markedly softens early GI effects, and any higher weekly dose simply calls for more than one vial or a split across two sites

Once accumulated in the cell, Gln is intensively metabolized by GA encoded by the GLS gene