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Pitfall: large volumes can cause hyperchloremic metabolic acidosis and increased interstitial edema

One of the important oxidant responsive cis elements (transcription factor binding sites) regulating GCL genes is the AP-1 binding site also called the TRE element

-Glutamyltransferase, redox regulation and cancer drug resistance

pmid:3782078 5

Transient receptor potential vanilloid 1 (TRPV1) plays a particularly important role in increasing C-fiber excitability and neuronal inflammatory pathways during airway inflammation 86
