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Inflammation haptocorrin levels can increase due to granulocyte activation or as an acute phase response Decreased clearance: Renal failure decreased clearance of transcobalaminB12 complexes Mechanism: Most elevated B12 is not free or biologically active , but rather bound to haptocorrin , which has a long half-life and is increased in certain diseases

23;7;385-386 Smith D, Refsum H

[10] Its administration during pregnancy carries potential risks to fetal development, and it is not indicated for use once pregnancy is confirmed

Plus, the body very quickly urinates any excess of B12

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