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It is noteworthy that ORF3a has a TRAF-binding domain at the N terminus that can activate NF-B and the NLRP3 inflammasome 143 , suggesting an important role in the host immune response

f , Cell death quantification (% trypan blue + ) of H1299 cells from ( e )

Bible KC, Boerner SA, Kirkland K, Anderl KL, Bartelt Jr D, Svingen PA, Kottke TJ, Lee YK, Eckdahl S, Stalboerger PG, Jenkins RB and Kaufmann SH