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Following statistical adjustment for the Matsuda Insulin Sensitivity Index, these associations were substantially attenuated and ultimately abolished, suggesting that insulin resistance may serve as the primary underlying mechanism driving the development and progression of T2DM [93]

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Moreover, when employing a definition based on International Classification of Diseases (ICD) diagnostic codes, the prevalence of CKD was significantly reduced, with 775 cases per 100,000 population [5]