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Bacterial overgrowth syndrome is a disorder in which poor intestinal motility allows certain intestinal bacteria to grow excessively, causing diarrhea and malabsorption

It is generally easier to restore function when irritation is addressed before long-standing structural damage accumulates

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Another approach to modulate NNMT involves bisubstrate inhibitors, which are designed to resemble both the substrate (NAM) and the cofactor (SAM)