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First, many of the experimental agents evaluated in preclinical studies, including NLRP3 inhibitors, peptide-based interventions, and gene editing technologies, have unresolved safety concerns related to their long-term use in at-risk patient populations (e.g., pediatric patients and patients with concomitant comorbidities)

Nervous System Effects: Lightheadedness, dizziness, euphoria, drowsiness, or, rarely, seizures

Effect of the inclusion of rumen-protected amino acids in the diet of growing beef cattle on animal performance and meat quality

Sogut S, Zoroglu SS, Ozyurt H, Yilmaz HR, Ozugurlu F, Sivash E, Yetkin O, Yanik M, Tutkun H, Savas HA: Changes in nitric oxide levels and antioxidant enzyme activities may have a role in the pathophysiological mechanisms involved in autism