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Likewise, remarkable safety (i.e., LD50 higher than 2000 mg/kg through oral or intravenous route in mice) confirmed no adverse effect in toxicology studies (none of the animals died)

This occurs because the enzyme, dihydrofolate reductase, has limited capacity to reduce folic acid in mammalian cells, particularly in human cells (68)

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One compound, five research pathways: NAD+ salvage preservation, SAM-dependent methylation, sirtuin activation, lipogenesis suppression, and energy expenditure modulation