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Drug Metab Dispos 38:16651672 Kato Y, Kubo Y, Iwata D, Kato S, Sudo T, Sugiura T, Kagaya T, Wakayama T, Hirayama A, Sugimoto M, Sugihara K, Kaneko S, Soga T, Asano M, Tomita M, Matsui T, Wada M, Tsuji A (2010) Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1

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Further, subsequent in vivo and in vitro validation confirmed G-Rc mediated suppression of the PI3K-AKT/NF-B signaling axis (Xu et al., 2024)

(B) Mutant IDH1 and IDH2 enzymes catalyze a reaction wherein -KG is reduced to (R)-2-hydroxyglutarate (D-2-HG) with concomitant oxidation of NADPH to NADP +