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FUNCTIONS Body cells and tissues are threatened continuously by damage caused by toxic free radicals and reactive oxygen species (e.g.,peroxides) which are produced during normal oxygen metabolism,by other chemical reactions,and by toxic agents in the environment

When this balance is disrupted, the accumulation of free iron catalyzes harmful reactions that culminate in lipid peroxidation and ultimately results in ferroptotic cell death

5 There are three isomers of COX: COX-1, COX-2, and COX-3

[DOI] [PubMed] [Google Scholar] Vlaming MLH, Mohrmann K, Wagenaar E, de Waart DR, Oude Elferink RPJ, Lagas JS, van Telligen O, Vainchtein LD, Rosing H, Beijnen JH, Schellens JHM, Schinkel AH

Schierwagen R, Uschner FE, Ortiz C, Torres S, Brol MJ, Tyc O, et al