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Activation of MC1R has been associated with upregulation of melanogenesis, potentially leading to increased melanin synthesis and transfer of melanosomes to adjacent keratinocytes, which could contribute to the development of visible mucosal pigmentation [23,24]

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Some common pigmented oral lesions include: Melanotic Macule : As described earlier, melanotic macule is a benign pigmented lesion typically found on the lips or oral mucosa

Esophageal varices Esophageal varices are enlarged veins in the esophagus (often linked to severe liver disease)