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For T cells, triptolide is reported to overturn T cell suppression, particularly CD4 + T cells subset in glioma (T98G) cells under IFN- treatment, while significantly decreases the proportion of Tregs in the spleen and axillary lymph nodes of melanoma (B16-F10) bearing mice, thereby impairing their suppressive function through the down-regulation of Foxp3, IL-10, and transforming growth factor in both protein and mRNA levels [974, 975]
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Nov 17 2009;106(46):19432-7
Transient Receptor Potential Canonical 5 (TRPC5): Regulation of Heart Rate and Protection against Pathological Cardiac Hypertrophy
Xiong J, Quan J, Qin C, Wang X, Dong Q, Zhang B
