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Description
Vitamin B12 deficiency is common amongst older adults who do not have enough hydrochloric acid in their stomach to absorb Vitamin B12 naturally, individuals who take stomach acid-altering medications or antibiotics frequently, individuals who have a gastrointestinal conditions, vegetarians/ vegans, and individuals with pernicious anemia

Yu TX, Kalakonda S, Liu X, Han N, Chung HK, Xiao L, et al

But many patients with chronic bloating, fatigue, food sensitivities, and gut dysfunction come back from a GI workup with a colonoscopy that's "normal" and no answers

En resumen, aunque no se ha identificado un receptor nico para DSIP, sus efectos parecen mediarse por modulaciones en circuitos de sueo, dolor y estrs, actuando tanto a nivel sinptico (GABA/Glutamato) como neuroendocrino (ACTH, GH, etc.), lo que le confiere un amplio espectro fisiolgico
JAMA 334 , 12311234 (2025)
