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18 Prevention Because of potential interactions from prolonged medication use, physicians should consider screening patients for vitamin B 12 deficiency if they have been taking proton pump inhibitors or H 2 blockers for more than 12 months, or metformin for more than four months
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This is further supported by lack of differences in intestinal MPO and fecal calprotectin concentrations between cirrhotic patients and controls

Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy
