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292,293 If dysregulated by external (e.g., exposure to pollution or smoking) or internal (e.g., neurodegenerative or inflammatory) insults, activation of these systems can lead to oxidative stress with diverse ramifications

Human evidence is extremely limited, consisting of three small pilot studies lacking rigorous controls

It is commonly used in peptide therapy and other medical applications

Although siRNA-mediated downregulation of NOS2 and 3 did not impact on erlotinib resistance (not shown), NOS1 silencing sensitised PC9ER cells to erlotinib (Figure 5b)

Pyroptosis in neurodegenerative diseases: from bench to bedside