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Additionally, a thorough study upon 16 cell lines harboring different p53 status elucidated that RITA can exert its apoptotic effects not only on wild-type 53 or mutant p53 but also in p53-null cells in a caspase- and BAX/BAK-dependent manner via activation of JNK/SAPK and p38 [724]

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doi: 10.1016/s0959-440x(98)80037-7 115 ProstALBlocAHussyNDerandRVivaudouM

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