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In this review, we outline the current knowledge regarding the molecular mechanisms that underlie BCBM provide an overview of the research models current used to study the process, particularly the relevance of the BBB in extravasation

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Once testing had been completed, histological examination of the animals brain sections was conducted (Fig

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The researchers also conducted RNA-sequencing, which apparently pointed to reduced activity of pathways involved in ECMreceptor interaction and focal adhesion, alongside lower levels of key ECM proteins such as fibronectin, tenascin C, laminin, thrombospondin-2, and Hmmr