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Description
The enhanced drug bioavailability caused by piperine is due to its potent inhibition of drug metabolism, being able to inhibit human P-glycoprotein and CYP3A4, while it interferes with UDP-glucose dehydrogenase and glucuronidation activities in liver
In liver biopsies of patients with NAFLD, advanced disease was associated with general DNA hypomethylation, suggesting less transcriptional control [135]
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i.e., it is not a potential pro-oxidant [43]
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