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The overexpression of arginine methyltransferase 5 (PRMT5) in solid and hematological tumors leads to the elevation of the methylation level of arginine residues on functionally related proteins in tumor cells, which affects cell cycle regulation, mRNA splicing, cell differentiation, signal transduction, and other physiological processes

Liang Z, Liu Y, Sun X, Lin J, Yao J, Song Y, et al

OSCP1 encodes a widely substrate-specific organic solute carrier protein, and its high methylation restricts the transport of imatinib into nasopharyngeal cancer cells, resulting in imatinib resistance

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