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A deficiency in this vital nutrient can lead to a range of health issues, including fatigue, weakness, anaemia, and neurological problems

[1] For example, if a 2 mL dose (full 200 mg thiamine, 200 mg niacinamide) is to be given IV, a nurse might mix it into 50 mL of saline and infuse over 15-30 minutes

Without treatment, this leads to megaloblastic anaemia and potentially serious neurological complications

In phase 2b clinical trials, this drug achieved degrees of weight loss that were significantly greater than those achieved with any other currently available antiobesity drug [76]

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