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Description
it downregulates NRF2 in leukemia (K-562 and HL-60) cells, increasing ROS and lipid oxidation to sensitize cells to doxorubicin (DOX), inhibits GPX4 in glioblastoma (U-87 MG and U251-MG) cells through the NRF2/SLC7A11/GPX4 axis to promote lipid peroxide accumulation, and enhances ferroptosis in NSCLC (A549) cells by increasing ROS via the NF- B pathway while simultaneously reducing drug resistance proteins such as P-gp and GPX4 [977, 996,997,998]
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In the future, this limitation is likely to be addressed by the availability of stabilised synthetic pharmaceutical grade SFN (e.g
Proteomic analysis of the acid-soluble organic matrix of the chicken calcified eggshell layer
