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Curr Drug Metab 12:667678
The manufacturer suggests timing the final dose 46 hours before hard work to build high blood levels
Further complicating matters is the fact that when TG are elevated and LDL-C is driven to very low levels, the accuracy of the Friedewald equation is severely compromised
Those authors concluded that dithiothreitol could induce the unfolded protein response and this would lead to an over-expression of the SPT LCB1 subunit mRNA, partially recovering its activity 75
