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Completed Phase II and III clinical trials have indicated that the agent has a nonoverlapping toxicity profile and synergistic effects with carboplatin, paclitaxel, and anthracycline, has no cross-drug resistance and is well tolerated, with patients mostly reporting fatigue and nausea

Other functions of nitric oxide: NO is a potent inhibitor of platelet adhesion and aggregation (by activating the cGMP pathway)

Brazel D, Park CJ, Nagasaka M

CBS News

An improved understanding of the biological factors underlying gender disparities in bladder cancer has the potential to reveal new sex/gender-specific therapeutic vulnerabilities, which could ultimately benefit all patients