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Both ether lipid-deficient mouse models and human patients with ether lipid deficiency often display defects in myelination in both the central and peripheral nervous systems (da Silva et al., 2012)

Thompson, M

2.9.1 Phase 1 A total of 48 female Mus musculus C57BL/6 (FMO3 +/+) strain WT mice, who were 8 weeks old, were divided into eight groups: six groups were based on the compound to be tested and the other two groups were, respectively, the positive control (FMC treatment) and the negative control (only phosphate-buffered saline treatment)

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Lipopolysaccharide (LPS), a component of the cell membrane in intestinal Gram-negative bacteria, can trigger an inflammatory response even in small amounts when released into the circulation, subsequently affecting liver function 30