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The finding of increased risk with AEDs of varying mechanisms of action and across a range of indications suggests that the risk applies to all AEDs used for any indication

The product should not be used by children, pregnant women or nursing mothers

F.AbdullahL.MullanM

Discussion Cutaneous ADR, usually grade 1 and grade 2 rashes are commonly seen with pemetrexed use, whereas Pirard-Franchemont et al [2] highlighted the difficulties interpreting these reactions as they are frequently labelled using the unspecific term skin rash

Despite the limited data from human trials, current studies have focused on specific molecular mechanisms and used representative animal models of PD