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However, it should be emphasized that vitamins B12 and B6 are also essential cofactors in the process of metabolizing hydroxy citric acid, in addition to folate [46, 47]

This can cause fatigue, weight gain, disrupted sleep cycles, and more

Wonder if there's a link there then

Increased serum vitamin B12 levels are associated with adult-onset Stills disease with reactive macrophage activation syndrome

Yes, but people with absorption issues (due to age, diet, or health conditions) may not get sufficient B12 from pills alone
