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Specifically, immunotherapy-induced tumor-infiltrating CD8 + T cells produce IFN-, which can enhance FGF2 signaling or upregulate branched-chain amino acid aminotransaminase 1 (BCAT1), enhancing the tumor stemness that confers the cross-tolerance to immunotherapy, chemotherapy and TKIs [131, 132]

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In mice, administration of LPS induces an acute lung injury similar to clinical ARDS, with production of inflammatory cytokines, leukocyte infiltration in the lung, and pulmonary edema

Herein, we comprehensively summarize H 2 delivery approaches and analyze the merits and limitations of each modality