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Therefore, it remains unclear if ER mutations are clinically relevant to antiestrogen resistance (Levenson et al ., 1997)

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Studies have shown that natural bioactive compounds from TCM (e.g., berberine, curcumin) contribute to synergistic anti-inflammatory and antioxidant effects, as well as enhanced drug-targeted delivery, while TCM formulations (e.g., Gegen Qinlian Decoction, Xilei San) exert holistic multi-target regulation by inhibiting key inflammatory pathways such as nuclear factor-kappa B (NF-B) and mitogen-activated protein kinase (MAPK), modulating gut microbiota composition, and restoring mucosal barrier function