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doi: 10.1002/ptr.6004 107 WangSCaiRMaJLiuTKeXLuHet al

This review highlights the biocatalyst-mediated synthesis of nicotinic-acid- and nitrile-metabolizing enzymes through state-of-the-art omics-based techniques to improve enzyme catalytic efficiency and stability via various approaches

In plain English: most peptides plug into a receptor on the cell surface and trigger a signal from there
J., Armour S., and Barbara D

These should prompt immediate medical review