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Epidemiological evidence from Zaire for a dietary etiology of konzo, an upper motor neuron disease

Generation of hydrogen peroxide by incidental metal ion-catalyzed autooxidation of glutathione
In parallel, awareness of the role of nutrition, has grown significantly, extending across broader segments of the population and encompassing an ever-wider range of diseases, including thyroid disorders

10.1016/j.pathophys.2006.05.007 13
Clinical observations have demonstrated that plasma betaine levels in patients with cirrhosis are associated with disease severity and decrease after liver transplantation, indicating their association with disease progression (137)
