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Therefore, these observations suggest that downregulating the expression and activity of the aforementioned proteins associated with melanosome transport may be useful for reversing the process of skin hyperpigmentation

The naturally occurring peptide GHK-Cu (GHK from glycyl-L-histidyl-L-lysine bound to a copper ion), which affects 31.2% of the human genes by either activating or deactivating them (based on a criterion of a reduction or increment in gene activity of more than 50%), meaning that it works by inducing epigenetic alterations in the cells

Calcium oxalate urolithiasis also occurs in hyperuricemic patients

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[DOI] [PMC free article] [PubMed] [Google Scholar] 657.Berthiaume A-A, Schmid F, Stamenkovic S, Coelho-Santos V, Nielson CD, Weber B, Majesky MW, Shih AY