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Journal of Hematology & Oncology 11, 64
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Indeed, the PDH complex, which decarboxylates glycolytically derived pyruvate to acetyl coenzyme A and links cytoplasmic glycolysis to the mitochondrial tricarboxylic acid (TCA) cycle, is modulated by reversible phosphorylation by PDH kinase (PDK)
Conversely, a synthetic CPT1 activator, C75, significantly reduced the symptom of kidney fibrosis in an FA-induced murine model (Kang et al., 2015)
