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[ 38 ] In contrast, antioxidants, such as vitamins C and E and Nacetylcysteine (NAC), prevent BACH1 degradation and inhibit the release of free heme by lowering ROS levels, [ 39 ] since ROS stimulates free heme release through the oxidization of hemecontaining proteins

3.2.1 PINK1/Parkin mediated mitophagy The pathway consisting of PINK1 and Parkin is a key participant in mitophagy, as well as the most common and classical pathway of autophagic mitochondria (Lazarou et al., 2015)

Once inside, it sheds the cloak and regains its active form

[DOI] [PubMed] [Google Scholar] 133.Hessl D., Libero L., Schneider A., Kerns C., Winder-Patel B., Heath B., Lee J., Coleman C., Sharma N., Solomon M., et al

An important limitation of the present study is the substantial imbalance in case numbers across ancestry groups: European ancestry participants (2,302 cases) comprise the largest group, followed by African ancestry (1,339 cases), with considerably fewer cases among Admixed American/Latino participants (465 cases)
