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Unlike its cyclic counterpart Melanotan II, MT-1 retains a linear backbone analogous to the 13-amino-acid natural -MSH sequence, differing primarily in a norleucine substitution at position 4 and a D-phenylalanine at position 7 (Nle-D-Phe--MSH), which confer receptor selectivity and enhanced metabolic stability

Analysis: While analysis of lipid A per se is a daunting technical challenge, requiring advanced mass spectrometric and other spectroscopic techniques allied to liquid chromatography, it is relatively a much easier task to detect and quantify the 3hydroxy-fatty acid constituents, mainly 3hydroxytetradecanoic acid, in plasma and other tissues as a means of evaluating endotoxin levels in patients infected with Gram-negative bacteria

A network-based analysis of systemic inflammation in humans

some of what it once gave us comes from elsewhere