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Apart from its metabolic effects, GLP-1 has also cholangioprotective effects against apoptosis and attenuating the reactive cholangiocyte phenotype.196 197 The BA sequestrant colesevelam and ASBT inhibitors (lopixibat and A4250) completely reversed liver and bile duct injury in Mdr2/Abcb4 / mice,198200 indicating that interruption of enterohepatic circulation of BAs may have therapeutic potential for attenuating cholestatic liver injury beyond their currently explored role in treatment of pruritus.189 Inhibition of ileal BA uptake protects against hepatic steatosis and restored insulin sensitivity in high-fat diet-fed mice, effects which are mediated by a marked shift in hepatic BA composition, with a reduction in hydrophilic, FXR antagonistic species and an increase in FXR agonistic BAs.201 However, clinical studies in human NASH with resins and ASBT inhibitors have so far been disappointing.202 Inhibition of NTCP by Myrcludex B (bulevirtide), a small peptide inhibitor originally designed to prevent hepatitis B virus uptake via NTCP, may also reduce intrahepatic BA levels.203 However, small molecule inhibitors of NTCP can also prevent HBV infection without interrupting BA uptake.204 Moreover, several drugs such as rosiglitazone, zafirlukast and sulfasalazine inhibit NTCP.205 In a chemical mouse model of sclerosing cholangitis NTCP inhibition by Myrcludex B improved hepatic inflammation and fibrosis.206 However, this therapeutic approach has so far not yet been tested clinically for cholestasis

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Alanine, arginine, cysteine, and proline, but not glutamine, are substrates for, and acute mediators of, the liver--cell axis in female mice

Hepatobiliary scintigraphy in the evaluation of feline liver disease