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Oxidative stress-induced formation of methionine sulfoxide can spontaneously react with hydroxyl radical and generates methyl radical that non-specifically and non-enzymatically methylate DNA cytosine and may affect the epigenome 38

For instance, doxorubicin, a topoisomerase inhibitor, induces DNA damage in cancer cells by interfering with topoisomerases and unwinding supercoiled DNA 24

Mediators Inflamm 2013

There is evidence that the reduction of UA in PD might reflect an increase in its metabolic removal, with elevated serum concentrations of allantoin, its immediate oxidative metabolite 23

IV Administration When initiating or changing an IV bag of fluids or medications, it is important to remember these items: IV fluids are a medication