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Int J Mol Sci 20:4018

Development 120 , 30193031 (1994)
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As cholesterol levels in the cell increase, due to de novo synthesis, cholesterol will bind to SCAP and prevent translocation of the complex to the Golgi, leading to a decrease in transcription of the reductase gene and thus less reductase protein being produced (figure 6.4)

Journal of neuroinflammation 10 , 142, (2013)