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[DOI] [PMC free article] [PubMed] [Google Scholar] 96.Ismail S, Elshimali Y, Daoud A, Alshehabi Z

It is in Phase 3 investigational trials as a "next generation" weight loss medication with potentially fewer side effects compared to single-receptor predecessors like Semaglutide or dual receptor meds like Tirzepatide
Moreover, KRAS mutation can drive reprogramming of glucose metabolism, and a perfect combination of the two requires a lot of prospective studies before they can truly serve for clinical monitoring (Figure 4)
Has OPALESCE been approved by the Medicines Council of SA

doi: 10.1016/j.biochi.2018.05.012
