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In order to trap HQ in the active site of TyrBm, mature crystals were soaked with zinc instead of copper ions to prevent enzymatic activity 22,35,40

T., Schachter, S., & Rotenberg, A

The importance of ECM cleavage in this process is evident from the phenotype of mice lacking metalloproteinases: a lack of MMP11 leads to a decreased periductal collagen content and decreased mammary gland morphogenesis 63

Bannister SC, Smith CA, Roeszler KN, Doran TJ, Sinclair AH, Tizard MLV

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